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RNF25 - ring finger protein 25 Gene

Also Known as AO7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64320

About RNF25

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,663,892-218,672,002 (from NCBI)

This gene has 6 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 11.2), thyroid (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating Enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

RNF25 Products (1)

mRNA	Protein	Name
NM_022453.3	NP_071898.2	E3 ubiquitin-protein ligase RNF25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	12748188	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18757723	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	26475854	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12748188	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	27863242	GOA
involved in protein-RNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	37951215	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	27863242	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27863242	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	12748188	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	27863242	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12748188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF25 Protein Structure

RWD

zf-RING_2

0
100
200
300
400
459 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF25	RING-type E3 ubiquitin transferase RNF25

RNF25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF25	Q96BH1	KCTD21	Homo sapiens	Q4G0X4	Y2H Prey Pooling	32296183
Intra	RNF25	Q96BH1	KCTD21	Homo sapiens	Q4G0X4	Y2H Array	32296183
Intra	RNF25	Q96BH1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RNF25	Q96BH1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RNF25	Q96BH1	UBE2E2	Homo sapiens	Q96LR5	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2D2	Homo sapiens	P62837	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2D2	Homo sapiens	P62837	Y2H Array	19690564
Intra	RNF25	Q96BH1	UBE2D3	Homo sapiens	P61077	Y2H Array	19690564
Intra	RNF25	Q96BH1	UBE2D3	Homo sapiens	P61077	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2D3	Homo sapiens	P61077	Y2H Array	19549727
Intra	RNF25	Q96BH1	UBE2E3	Homo sapiens	Q969T4	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2E3	Homo sapiens	Q969T4	Y2H Array	19690564
Intra	RNF25	Q96BH1	UBE2E1	Homo sapiens	P51965	Y2H Array	19690564
Intra	RNF25	Q96BH1	UBE2E1	Homo sapiens	P51965	Y2H Array	19549727
Intra	RNF25	Q96BH1	UBE2E1	Homo sapiens	P51965	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2E1	Homo sapiens	P51965	Anti Tag CoIP	28514442
Intra	RNF25	Q96BH1	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	RNF25	Q96BH1	UBE2D4	Homo sapiens	Q9Y2X8	Anti Tag CoIP	33961781
Intra	RNF25	Q96BH1	UBE2D4	Homo sapiens	Q9Y2X8	Anti Tag CoIP	28514442
Intra	RNF25	Q96BH1	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19690564

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypomagnesemia 3, Renal	HOMG3 Renal Hypomagnesemia 3 Fhhnc Without Severe Ocular Involvement Renal Hypomagnesemia Type 3 Hypomagnesemia, Primary, Due To Defect In Renal Tubular Transport Of Magnesium Hypomagnesemia, Isolated Renal Hypomagnesemia, Familial, With Hypercalciuria And Nephrocalcinosis Familial Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement Isolated Renal Hypomagnesemia Primary Hypomagnesemia Due To Defect In Renal Tubular Transport Of Magnesium Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Without Severe Ocular Involvement Hypomagnesemia 3 Familial Hypomagnesemia With Hypercalciuria And Nephrocalcinosis Fhhnc Hhn Renal Hypomagnesemia Hypercalciuria Nephrocalcinosis Hypomagnesemia, Type 3, Renal Primary Hypomagnesemia
Progesterone-Receptor Positive Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177569	NVS1.1	Degrader	/	Unkown
HY-177757	NVS2.1	Degrader	99.90%	Unkown
HY-RS12084	RNF25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21736	Rnf25 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28253	Rnf25 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF25	VGNC	VGNC:76736
Bos taurus	RNF25	VGNC	VGNC:34060
Rattus norvegicus	RNF25	RGD	RGD:1311557
Felis catus	RNF25	VGNC	VGNC:64698
Mus musculus	RNF25	MGD	MGI:1890215
Canis familiaris	RNF25	VGNC	VGNC:45665
Others	RNF25	NCBI