SLC11A1 - solute carrier family 11 member 1 Gene

Also Known as LSH; NRAMP; NRAMP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6556

About SLC11A1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,382,273-218,396,894 (from NCBI)

This gene has 18 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in lung (RPKM 10.4), appendix (RPKM 8.8) and 7 other tissues.

Summary

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

SLC11A1 Products (1)

mRNA	Protein	Name
NM_000578.4	NP_000569.3	natural resistance-associated macrophage protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9730978	GOA
enables manganese ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9730978	GOA
enables metal cation:proton antiporter activity	IDA IDA: Inferred from direct assay	9730978	GOA
enables metal cation:proton antiporter activity	IGI IGI: Inferred from genetic interaction	17932044	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8537108	GOA
enables transition metal ion transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	17932044	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cadmium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	17932044	GOA
involved in cellular detoxification of cadmium ion	IGI IGI: Inferred from genetic interaction	17932044	GOA
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16510578	GOA
involved in iron ion transport	IDA IDA: Inferred from direct assay	9730978	GOA
involved in iron ion transport	IMP IMP: Inferred from mutant phenotype	16510578	GOA
involved in manganese ion transport	IDA IDA: Inferred from direct assay	9730978	GOA
involved in response to bacterium	IDA IDA: Inferred from direct assay	7717395	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	12070036	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	17932044	GOA
located in tertiary granule membrane	IDA IDA: Inferred from direct assay	12070036	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC11A1 Protein Structure

Nramp

0
100
200
300
400
500
550 a.a.

Protein Preferred Names	Protein Names
natural resistance-associated macrophage protein 1	Leishmaniasis resistance

Related Diseases

Diseases	Alias
Buruli Ulcer	Buruli Ulcer, Susceptibility To Buruli Ulcer Disease Mycobacterium Ulcerans Mycobacterium Ulcerans, Susceptibility To Bairnsdale Ulcer Daintree Ulcer Mossman Ulcer Searl Ulcer Searle'S Ulcer Bud
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Tularemia	Francisella Tularensis Infection Deerfly Fever Lemming Fever Ohara Disease Pahvant Valley Plague Rabbit Fever Yatobyo
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Visceral Leishmaniasis	Kala-Azar Leishmaniasis, Visceral Infection By Visceral Leishmaniasis Leishmaniasis Visceral Sahib Disease Ponos Burdwan Fever Mard El Bicha Sirkari Disease Indian Visceral Leishmaniasis Dumdum Fever Visceral Leishmaniasis Due To Leishmania Donovani
Brucellosis	Mediterranean Fever Malta Fever Undulant Fever Gibraltar Fever Bang'S Disease Maltese Fever Cyprus Fever Rock Fever Brucellosis Infection Brucella Infection
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Q Fever	Infection Due To Coxiella Burnetii Quadrilateral Fever Query Fever Nine Mile Fever Coxiella Burnetii Fever Q Fever Pneumonia Coxiellosis Pneumonia In Q Fever Australian Q Fever Balkan Grippe
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Septicemic Plague	Plague, Septicemic
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Adenitis Chronic Adenitis Acute Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Type 1 Diabetes Mellitus 7	Diabetes Mellitus, Insulin-Dependent, 7 Iddm7 Insulin-Dependent Diabetes Mellitus 7 T1D7
Salmonellosis	Salmonella Infections Salmonella Infection
Macs Syndrome	Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis Mycobacterium Avium Complex Disease Rin2 Syndrome Mycobacterium Avium-Intracellulare Infection Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis Mycobacterium Avium Complex Mycobacterium Avium Infection Infection Due To Mycobacterium Intracellulare Mac Disease Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome Rin2 Deficiency Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome MACS Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Iron Metabolism Disease	Iron Deficiency Iron Disorder Iron Metabolism Disorders Disorder Of Iron Metabolism Iron Fe Deficiency Iron Storage Disease Iron Storage Disorder
Type 1 Diabetes Mellitus 17	Diabetes Mellitus, Insulin-Dependent, 17 Iddm17 Insulin-Dependent Diabetes Mellitus 17 TID17 Insulin-Dependent Diabetes Mellitus-17
Gastrointestinal Tularemia	Enteric Tularemia Intestinal Tularaemia
Primary Bacterial Infectious Disease
Laryngeal Tuberculosis	Tuberculosis, Laryngeal
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Urogenital Tuberculosis	Tuberculosis, Urogenital Genitourinary Tuberculosis
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Borderline Leprosy	Midborderline Leprosy Borderline Or Dimorphous Leprosy Leprosy, Borderline
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
Indeterminate Leprosy	Uncharacteristic Leprosy
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Microcytic Anemia	Iron-Refractory Iron Deficiency Anemia
Extrapulmonary Tuberculosis	EPTB Tuberculosis, Extrapulmonary
Mucocutaneous Leishmaniasis	American Cutaneous Leishmaniasis American Mucocutaneous Leishmaniasis Cutaneous Leishmaniasis, American Mucocutaneous Leishmaniasis, American New World Cutaneous Leishmaniasis Leishmaniasis, Mucocutaneous Espundia Leishmania Braziliensis Infection
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12994	SLC11A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19551	Slc11a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26047	Slc11a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC11A1	RGD	RGD:1601463
Bos taurus	SLC11A1	VGNC	VGNC:34663
Felis catus	SLC11A1	VGNC	VGNC:65186
Macaca mulatta	SLC11A1	VGNC	VGNC:77382
Canis familiaris	SLC11A1	VGNC	VGNC:46216
Mus musculus	SLC11A1	MGD	MGI:1345275
Others	SLC11A1	NCBI