CHAF1B - chromatin assembly factor 1 subunit B Gene

Also Known as CAF1; MPP7; CAF-1; CAF1A; CAF1P60; CAF-IP60; MPHOSPH7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8208

About CHAF1B

Cytogenetic location: 21q22.12-q22.13 Genomic coordinates (GRCh38): 21:36,385,392-36,419,015 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in bone marrow (RPKM 2.7), testis (RPKM 2.6) and 25 other tissues.

Summary

Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during Mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]

CHAF1B Products (1)

mRNA Protein Name
NM_005441.3 NP_005432.1 chromatin assembly factor 1 subunit B

CHAF1B Protein Structure

WD40

WD40: WD domain, G-beta repeat (14 - 45)

WD40

WD40: WD domain, G-beta repeat (61 - 94)

WD40

WD40: WD domain, G-beta repeat (119 - 157)

WD40

WD40: WD domain, G-beta repeat (162 - 199)

WD40

WD40: WD domain, G-beta repeat (343 - 370)

CAF-1_p60_C

CAF-1_p60_C: Chromatin assembly factor complex 1 subunit p60, C-terminal (381 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

chromatin assembly factor 1 subunit B

  • CAF-1 subunit B

CHAF1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHAF1B Q13112 ASF1B Homo sapiens Q9NVP2
TAP
27705803
Cross: Cross-species interaction Intra: Intraspecies interaction

CHAF1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P82254 p60 CAF1 Antibody (YA1999) WB, IHC-P, ICC/IF, FC, IP Human

Related Diseases

Diseases Alias
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Luminal Breast Carcinoma A

  • Breast Tumor Luminal

  • Luminal A Breast Carcinoma

  • Luminal Breast Cancer
Myeloid Leukemia Associated With Down Syndrome
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Acute Megakaryocytic Leukemia

  • Acute Megakaryoblastic Leukemia

  • Acute Megakaryoblastic Leukaemia

  • Megakaryocytic Myelosis

  • Thrombocytic Leukaemia

  • Amkl

  • Aml M7

  • Acute Myeloblastic Leukemia Type 7

  • Acute Myeloid Leukemia M7

  • Megakaryoblastic Leukemia Acute

  • Leukemia, Megakaryoblastic, Acute

  • Acute Myeloid Leukaemia, M7

  • Acute Megakaryocytic Leukaemia

  • Acute Megakaryoblastic Leukaemia, Fab M7

  • Fab M7

  • Malignant Megakaryocytosis

  • M7 - Acute Megakaryoblastic Leukaemia

  • Megakaryoblastic Leukaemia

  • Megakaryocytic Leukaemia

  • Acute Megakaryoblastic Leukaemia, Nos

  • Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02595 CHAF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20142 Chaf1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26646 Chaf1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CHAF1B MGD MGI:1314881
Macaca mulatta CHAF1B VGNC VGNC:80859
Canis familiaris CHAF1B VGNC VGNC:39190
Bos taurus CHAF1B VGNC VGNC:27267
Rattus norvegicus CHAF1B RGD RGD:1307634
Felis catus CHAF1B VGNC VGNC:60836
Others CHAF1B NCBI