CLCA2 - chloride channel accessory 2 Gene

Also Known as CACC; CACC3; CLCRG2; CaCC-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9635

About CLCA2

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,424,171-86,456,553 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 67.2), skin (RPKM 43.6) and 1 other tissue.

Summary

This gene encodes a member of the calcium-activated Chloride Channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast Cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in Cancer cell lines. [provided by RefSeq, Sep 2016]

CLCA2 Products (1)

mRNA Protein Name
NM_006536.7 NP_006527.1 calcium-activated chloride channel regulator 2 preproprotein

CLCA2 Protein Structure

CLCA

CLCA: Calcium-activated chloride channel N terminal (8 - 265)

VWA_2

VWA_2: von Willebrand factor type A domain (312 - 470)

(494 - 674)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 943 a.a.
Protein Preferred Names Protein Names

calcium-activated chloride channel regulator 2

  • CLCA family member 2, chloride channel regulator

Related Diseases

Diseases Alias
Maxillary Cancer

  • Maxillary Neoplasm

  • Maxillary Neoplasms

  • Upper Jaw Bone Cancer
Progressive Familial Heart Block, Type Ib

  • Progressive Familial Heart Block Type Ib

  • PFHB1B

  • Pfhbib

  • Progressive Familial Heart Block Type 1b

  • Heart Block Progressive Familial Type 1b

  • Progressive Familial Heart Block 1b

  • Cardiac Conduction Block

  • Right-Bundle Branch Block

  • Heart Block, Familial, Progressive, Type 1b

  • Heart Block

  • Right Bundle Branch Block
Jaw Cancer

  • Jaw Neoplasms

  • Jaw Neoplasm

  • Neoplasm Of Jaw

  • Cancer Of Jaw
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Ectodermal Dysplasia 4, Hair/Nail Type

  • Pure Hair And Nail Ectodermal Dysplasia

  • ECTD4

  • Ectodermal Dysplasia, Pure Hair-Nail Type

  • Ectodermal Dysplasia, 'Pure' Hair/Nail Type

  • Hned

  • Hair-Nail Ectodermal Dysplasia

  • Phned

  • Ectodermal Dysplasia Pure Hair-Nail Type

  • Ectodermal Dysplasia, 'Pure' Hair-Nail Type

  • Dysplasia, Ectodermal, Type 4, Hair/Nail
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02749 CLCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CLCA2 VGNC VGNC:60919
Rattus norvegicus CLCA2 RGD RGD:1304894
Bos taurus CLCA2 VGNC VGNC:27393
Canis familiaris CLCA2 VGNC VGNC:39297
Macaca mulatta CLCA2 VGNC VGNC:71233
Mus musculus CLCA2 MGD MGI:2139758
Others CLCA2 NCBI