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NR1D2 - nuclear receptor subfamily 1 group D member 2 Gene

Also Known as RVR; BD73; EAR-1R; REVERBB; REVERBbeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9975

About NR1D2

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,945,286-23,980,617 (from NCBI)

This gene has 5 transcripts (splice variants), 474 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 35.4), ovary (RPKM 18.9) and 25 other tissues.

Summary

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

NR1D2 Products (2)

mRNA	Protein	Name
NM_001145425.2	NP_001138897.1	nuclear receptor subfamily 1 group D member 2 isoform 2
NM_005126.5	NP_005117.3	nuclear receptor subfamily 1 group D member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17892483	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17892483	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17892483	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17892483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR1D2 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
nuclear receptor subfamily 1 group D member 2	V-erbA-related protein 1-related

NR1D2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	NR1D2	Q14995	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	NR1D2	Q14995	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
Intra	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	NR1D2	Q14995	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	NR1D2	Q14995	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	NR1D2	Q14995	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	NR1D2	Q14995	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	NR1D2	Q14995	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	NR1D2	Q14995	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	NR1D2	Q14995	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	NR1D2	Q14995	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NR1D2	Q14995	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	NR1D2	Q14995	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	NR1D2	Q14995	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	NR1D2	Q14995	GRN	Homo sapiens	P28799	Y2H Array	32814053
Cross	NR1D2	Q14995	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atrioventricular Septal Defect	AVSD Atrioventricular Canal Defect Avcd Endocardial Cushion Defect Ecd Avc Defect Atrioventricular Septal Defect, Susceptibility To, 1 Atrioventricular Septal Defect 1 Endocardial Cushion Defects Septal Defect, Atrioventricular Atrioventricular Defect With Atrial Shunting Only Incomplete Atrioventricular Septal Defect With Isolated Atrial Component Incomplete Atrioventricular Canal Defect With Isolated Atrial Component Primum Atrial Septal Defect Partial Atrioventricular Canal Defect With Isolated Atrial Component Partial Atrioventricular Septal Defect, Ostium Primum Type Ostium Primum Atrial Septal Defect Partial Atrioventricular Canal Defect Partial Atrioventricular Septal Defect Atrial Septum Primum Defect Atrioventricular Canal Defect With Isolated Ventricular Component Atrioventricular Canal Defect With Isolated Ventricular Communication Atrioventricular Septal Defect With Isolated Ventricular Component Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect Intermediate Atrioventricular Canal Defect Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices Intermediate Atrioventricular Septal Defect Transitional Atrioventricular Canal Defect Transitional Atrioventricular Septal Defect Complete Atrioventricular Canal With Atrial And Ventricular Components Complete Atrioventricular Canal Defect Complete Atrioventricular Septal Defect
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09528	NR1D2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NR1D2	MGD	MGI:2449205
Canis familiaris	NR1D2	VGNC	VGNC:43941
Felis catus	NR1D2	VGNC	VGNC:68543
Macaca mulatta	NR1D2	VGNC	VGNC:75503
Bos taurus	NR1D2	VGNC	VGNC:32229
Rattus norvegicus	NR1D2	RGD	RGD:628828
Others	NR1D2	NCBI