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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
143 Results for "
GPR1
" in MedChemExpress (MCE) Product Catalog:
Products (143)
143 Results for "GPR1" in MCE Product Catalog:
2
2 Cited Publications
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GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of 7.62.
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1 Cited Publications
Synonyms: GPR183 antagonist-1
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SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice .
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1 Cited Publications
Synonyms: GPR132 antagonist 1
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NOX-6-18 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. NOX-6-18 has promote insulin secretion activity with an EC50 value of 0.7 μM .
1
1 Cited Publications
Cat. No.: HY-P87317
Synonyms: C1orf139 antibody; DKFZp686I0788 antibody; Evenness interrupted, Drosophila, homolg of antibody; EVI antibody; FLJ23091 antibody; G protein coupled receptor 177 antibody; GPR 177 antibody; Integral membrane protein GPR177 antibody; MGC131760 antibody; MGC14878 antibody
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b, and does not activate the mouse homologous receptor PUMA-G. GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol (HY-B0468)-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin (HY-B0143), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis .
Cat. No.: HY-P10495A
Cat. No.: HY-177116
CAS No.: 252280-67-4
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GPR15 antagonist-1 (Compound 5) is a GPR15 antagonist. G protein-coupled receptor 15 (GPR15) is an extensively studied GPCRs involving HIV infection, colonic inflammation, and smoking-related diseases .
Cat. No.: HY-170589
CAS No.: 1574405-61-0
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GPR17 antagonist 1 (compound 978) is a GPR17 antagonist. GPR17 antagonist 1 can be used in the study of diabetes and obesity .
Cat. No.: HY-157939
CAS No.: 3054870-33-3
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GPR183 antagonist-3 (compound 33) is an oral active GPR183 antagonist with the IC50 of 8.7 μM. GPR183 antagonist-3 displays strong in vitro antimigration and anti-inflammatory activity in monocytes, and improves the pathological symptoms of DSS-induced experimental colitis .
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GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research .
Cat. No.: HY-50162
CAS No.: 1050506-75-6
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GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F1. GPR120 modulator 1 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .
Cat. No.: HY-50172
CAS No.: 1050506-87-0
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GPR120 modulator 2 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .
Cat. No.: HY-175306
CAS No.: 2380033-51-0
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GPR183 inverse agonist-1 (Compound 78) is a GPR183 inverse agonist. GPR183 inverse agonist-1 inhibits the GPR183-mediated Gi activation and β-arrestin2 recruitment, and blocks PBMC migration. GPR183 inverse agonist-1 can be used for inflammatory, autoimmune and neoplastic disorders research .
Cat. No.: HY-P10495
CAS No.: 1778685-49-6
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Cat. No.: HY-RS05653
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Gpr119 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr119 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164311
CAS No.: 3039853-91-0
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GPR17 modulator-1 (Compound 2-046) is a modulator for G protein-coupled receptor 17 GPR17, with an IC50<10 nM for hGPR17 in CHO. GPR17 modulator-1 exhibits moderate pharmacokinetic characteristics in mice. GPR17 modulator-1 ix blood-brain barrier (BBB) permeable .
Cat. No.: HY-P10378
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Cat. No.: HY-176817
CAS No.: 944559-31-3
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GPR109 receptor agonist-3 is an orally active GPR109 receptor agonist, with an IC50 of 310 nM.
GPR109 receptor agonist-3 retains the antioxidation and cytoprotection of Lipoic acid (HY-18733). GPR109 receptor agonist-3 reduces total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and increases high-density lipoprotein cholesterol (HDL-C) in high-fat diet-fed rats. GPR109 receptor agonist-3 can be used for the study of atherosclerosis .
Cat. No.: HY-RS17979
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Gpr18 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr18 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17514
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Gpr132 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr132 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
