306935-41-1
Chemical Structure
GPR109 receptor agonist-1
- CAS No.: 306935-41-1
- Formula:C10H11N3O2
- Molecular Weight:205.22
IUPAC Name: 1-isopropyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid
InChIKey: RUTVRAJKELSHCC-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(N(C(C)C)N=N2)C2=C1)O
Biological Activity: GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b, and does not activate the mouse homologous receptor PUMA-G. GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol (HY-B0468)-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin (HY-B0143), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis[1].
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GPR109 receptor agonist-1 | 99.94% | GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b, and does not activate the mouse homologous receptor PUMA-G. GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol (HY-B0468)-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin (HY-B0143), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis. | ||||||||||||||||||||
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Keywords
