1241280-25-0
1241280-25-0
Chemical Structure
SAE-14
Synonym(s): GPR183 antagonist-1
- CAS. Nr.: 1241280-25-0
- Formula:C19H19F3N2O2
- Molecular Weight:364.36
IUPAC Name: 3-(3,4-difluorophenyl)-N-(3-fluoro-5-morpholinophenyl)propanamide
InChIKey: SIVJKYRAPQKLIM-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
Biological Activity: SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].
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SAE-14 | 98.60% | SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. | ||||||||||||||||||||
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References
Keywords
