SH2B2 - SH2B adaptor protein 2 Gene

Also Known as APS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10603

About SH2B2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,285,141-102,321,711 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues.

Summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and Src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

SH2B2 Products (11)

mRNA	Protein	Name
NM_001359228.2	NP_001346157.1	SH2B adapter protein 2 isoform 2
NM_001359229.2	NP_001346158.1	SH2B adapter protein 2 isoform 2
NM_001359230.2	NP_001346159.1	SH2B adapter protein 2 isoform 3
NM_001359231.2	NP_001346160.1	SH2B adapter protein 2 isoform 3
NM_001393990.3	NP_001380919.2	SH2B adapter protein 2 isoform 3
NM_001393991.3	NP_001380920.2	SH2B adapter protein 2 isoform 2
NM_001393992.3	NP_001380921.2	SH2B adapter protein 2 isoform 3
NM_001393993.1	NP_001380922.1	SH2B adapter protein 2 isoform 2
NM_001393994.1	NP_001380923.1	SH2B adapter protein 2 isoform 2
NM_001393995.1	NP_001380924.1	SH2B adapter protein 2 isoform 7
NM_001394426.1	NP_001381355.1	SH2B adapter protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	9233773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15737992	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	9233773	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9233773	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9989826	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9989826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2B2 Protein Structure

Phe_ZIP

PH

SH2

0
200
400
600
671 a.a.

Protein Preferred Names	Protein Names
SH2B adapter protein 2	SH2 and PH domain-containing adapter protein APS

SH2B2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH2B2	O14492	CBL	Homo sapiens	P22681	ITC	18273061
Intra	SH2B2	O14492	CBL	Homo sapiens	P22681	Anti Tag CoIP	18273061

Cross: Cross-species interaction Intra: Intraspecies interaction

SH2B2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P83800	SH2B2 Antibody (YA3497)	IHC-P, FC, ELISA	Human
HY-P83800A	SH2B2 Antibody (YA3497)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Erythrocytosis, Familial, 7	ECYT7 Erythrocytosis 7 Familial Erythrocytosis 7 Erythrocytosis, Alpha-Globin Type Polycythemia, Alpha-Globin Type Alpha-Globin Type Erythrocytosis Alpha-Globin Type Polycythemia
Erythrocytosis, Familial, 6	ECYT6 Erythrocytosis 6 Familial Erythrocytosis 6 Erythrocytosis, Beta-Globin Type Polycythemia, Beta-Globin Type Beta-Globin Type Erythrocytosis Beta-Globin Type Polycythemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS12819	SH2B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SH2B2	MGD	MGI:1345171
Bos taurus	SH2B2	VGNC	VGNC:59364
Felis catus	SH2B2	VGNC	VGNC:65089
Rattus norvegicus	SH2B2	RGD	RGD:69284
Macaca mulatta	SH2B2	VGNC	VGNC:77257
Others	SH2B2	NCBI