PPARGC1B - PPARG coactivator 1 beta Gene

Also Known as PERC; ERRL1; PGC1B; PGC-1(beta)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 133522

About PPARGC1B

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,730,310-149,857,959 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 2.8), small intestine (RPKM 2.6) and 24 other tissues.

Summary

The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including Estrogen receptor alpha, nuclear respiratory factor 1, and Glucocorticoid Receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

PPARGC1B Products (3)

mRNA Protein Name
NM_001172698.2 NP_001166169.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
NM_001172699.2 NP_001166170.1 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 3
NM_133263.4 NP_573570.3 peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AF-2 domain binding IPI
IPI: Inferred from physical interaction
11854298 GOA
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
11854298 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
11854298 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
11854298 GOA
Biological Process GO Annotation Evidence References Source
involved in estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
11854298 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11854298 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23836911 GOA
Cellular Component GO Annotation Evidence References Source
part of mediator complex IDA
IDA: Inferred from direct assay
11854298 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11854298 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPARGC1B Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (904 - 955)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1023 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma coactivator 1-beta

  • PGC-1-related estrogen receptor alpha coactivator

PPARGC1B Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P81666 PGC1 beta Antibody (YA1411) WB, IP Human, Mouse, Rat
HY-P86532 PGC1 beta Antibody (YA6224) WB, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Diabetes Mellitus

  • Diabetes
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS10931 PPARGC1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPARGC1B VGNC VGNC:76134
Mus musculus PPARGC1B MGD MGI:2444934
Rattus norvegicus PPARGC1B RGD RGD:727948
Felis catus PPARGC1B VGNC VGNC:82420
Canis familiaris PPARGC1B VGNC VGNC:44838
Bos taurus PPARGC1B VGNC VGNC:33185
Others PPARGC1B NCBI