Med1 - mediator complex subunit 1 Gene

Also Known as RGD1559552

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497991

Summary

Enables DNA binding activity; nuclear receptor binding activity; and transcription coregulator activity. Contributes to ubiquitin protein Ligase activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in chromatin and nucleus. Part of protein-DNA complex and ubiquitin Ligase complex. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Med1 Products (1)

mRNA Protein Name
NM_001134361.1 NP_001127833.1 mediator of RNA polymerase II transcription subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20702579 RGD
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
20702579 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
20378540 RGD
enables general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
10037764 RGD
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
10037764 RGD
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
10037764 RGD
enables nuclear vitamin D receptor binding IDA
IDA: Inferred from direct assay
17786964 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
10037764 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
10037764 RGD
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
10037764 RGD
contributes to ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
12149480 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to thyroid hormone stimulus IDA
IDA: Inferred from direct assay
12034878 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10037764 RGD
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
12149480 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20702579 RGD
part of protein-DNA complex IDA
IDA: Inferred from direct assay
10037764 RGD
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
12149480 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-N10508 Calcitroic acid Ligand 85.0% Unkown
HY-N10508S Calcitroic acid-13C Ligand / Unkown
HY-RS08184 MBD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08278 MED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18247 Med1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19616 Mbd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22462 Cwc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24727 Med1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Med1 NCBI NCBI:5469