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EPN3 - epsin 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55040

About EPN3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,532,735-50,543,750 (from NCBI)

This gene has 17 transcripts (splice variants), 250 orthologues and 5 paralogues. Broad expression in stomach (RPKM 11.8), esophagus (RPKM 7.2) and 16 other tissues.

Summary

Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Located in clathrin-coated vesicle; nucleoplasm; and perinuclear region of cytoplasm. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EPN3 Products (1)

mRNA	Protein	Name
NM_017957.3	NP_060427.2	epsin-3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20709745	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	11359770	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20709745	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11359770	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11359770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPN3 Protein Structure

ENTH

UIM

0
100
200
300
400
500
600
632 a.a.

Protein Preferred Names	Protein Names
epsin-3	EPS-15-interacting protein 3

Related Diseases

Diseases	Alias
Adult Spinal Cord Ependymoma
Brain Ependymoma	Ependymal Tumor Of Brain Ependymoma Of Brain
Deafness, Autosomal Dominant 28	DFNA28 Autosomal Dominant Nonsyndromic Deafness 28 Autosomal Dominant Deafness 28 Deafness, Autosomal Dominant, 28 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28 Deafness, Autosomal Dominant, Type 28
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS04445	EPN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22162	Epn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28684	Epn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPN3	RGD	RGD:1306416
Bos taurus	EPN3	VGNC	VGNC:28548
Felis catus	EPN3	VGNC	VGNC:61914
Mus musculus	EPN3	MGD	MGI:1919139
Macaca mulatta	EPN3	VGNC	VGNC:72068
Canis familiaris	EPN3	VGNC	VGNC:40421
Others	EPN3	NCBI