SNRNP70 - small nuclear ribonucleoprotein U1 subunit 70 Gene

Also Known as RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6625

About SNRNP70

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,085,451-49,108,604 (from NCBI)

This gene has 10 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 63.5), spleen (RPKM 63.2) and 25 other tissues.

Summary

Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SNRNP70 Products (2)

mRNA	Protein	Name
NM_001301069.2	NP_001287998.1	U1 small nuclear ribonucleoprotein 70 kDa isoform 2
NM_003089.6	NP_003080.2	U1 small nuclear ribonucleoprotein 70 kDa isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	2467746	GOA
enables U1 snRNA binding	IDA IDA: Inferred from direct assay	21113136	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9447963	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9531537	GOA
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	2467746	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18559850	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9531537	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRNP70 Protein Structure

U1snRNP70_N

RRM_1

0
100
200
300
400
437 a.a.

Protein Preferred Names	Protein Names
U1 small nuclear ribonucleoprotein 70 kDa	U1 snRNP 70 kDa

SNRNP70 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRNP70	P08621	TIA1	Homo sapiens	P31483	Anti Bait CoIP	12486009
Intra	SNRNP70	P08621	SMN1	Homo sapiens	Q16637	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SMN1	Homo sapiens	Q16637	Pull Down	26828962
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	FRET	18559666
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SRSF1	Homo sapiens	Q07955	Anti Bait CoIP	18559666
Intra	SNRNP70	P08621	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	GTPBP2	Homo sapiens	Q9BX10	Validated Y2H	32296183
Intra	SNRNP70	P08621	CEP63	Homo sapiens	Q96MT8	Y2H	17043677
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Y2H Array	21988832
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Anti Tag CoIP	33961781
Intra	SNRNP70	P08621	CLK2	Homo sapiens	P49760	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Disease Of Mental Health	Mental Health Mental Disorders
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Diffuse Scleroderma	Diffuse Systemic Sclerosis Systemic Sclerosis, Diffuse Scleroderma, Diffuse Systemic Scleroderma Progressive System Sclerosis
Facial Hemiatrophy	Parry-Romberg Syndrome
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Heart Block, Congenital	Congenital Heart Block Heart Block Congenital Congenital Atrioventricular Block
Collagen Disease	Collagen Diseases Collagen Disorder
Epidermolysis Bullosa Dystrophica, Pretibial	Epidermolysis Bullosa, Pretibial Pretibial Dystrophic Epidermolysis Bullosa Deb-Pt Dystrophic Epidermolysis Bullosa, Pretibial Deb, Pretibial Pretibial Epidermolysis Bullosa Pretibial Deb Localized Dystrophic Epidermolysis Bullosa, Pretibial Form Localized Deb, Pretibial Form Epidermolysis Bullosa Dystrophica, Pretibial Type PR-DEB
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Crest Syndrome
Libman-Sacks Endocarditis	Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Localized Scleroderma	Morphea Localised Scleroderma Localized Fibrosing Scleroderma Circumscribed Scleroderma Localised Morphea Localised Morphoea Localized Morphea Scleroderma, Circumscribed Or Localised Scleroderma, Circumscribed Or Localized Scleroderma, Localized
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Cerebritis
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Autoimmune Disease Of Exocrine System
Raynaud Disease	Raynaud'S Disease Raynaud Phenomenon Raynaud'S Syndrome Raynaud'S Cold Fingers, Hereditary Raynaud'S Phenomenon Raynaud'S Disease/Phenomenon Raynauds Syndrome Raynauds Phenomenon Secondary Raynaud'S Phenomenon Raynaud Syndrome
Telangiectasis	Telangiectasia
Splenic Tuberculosis	Tuberculosis, Splenic
Hypotrichosis 13	HYPT13 Hypotrichosis With Woolly Hair Hypotrichosis, Type 13
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS13499	SNRNP70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21261	Snrnp70 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27780	Snrnp70 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRNP70	MGD	MGI:98341
Canis familiaris	SNRNP70	VGNC	VGNC:46609
Rattus norvegicus	SNRNP70	RGD	RGD:1307120
Macaca mulatta	SNRNP70	VGNC	VGNC:77673
Bos taurus	SNRNP70	VGNC	VGNC:35073
Others	SNRNP70	NCBI