LSD1-IN-27
Based on 1 publication(s) in Google Scholar
LSD1-IN-27 is an orally active LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer.
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- Purity: 98.88%
- CAS No.: 2904571-94-2
- 화학식: C24H25N3
- 분자량:355.48
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Epigenetics Compound Library
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Publications Citing Use of MedChemExpress (MCE) LSD1-IN-27
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Biological Activity
13 nM (LSD1)[1]
LSD1-IN-27 (Compound 5ac; 1-2 μM; 24-48 h) reduces the stemness and migration ability of gastric cancer cells[1].
LSD1-IN-27 (1-2 μM; 5 days) induces the accumulation of LSD1 substrate H3K4me1 and H3K4me2 in BGC-823 cells[1].
LSD1-IN-27 (1-2 μM; 5 days) suppresses the expression of PD-L1 and promoted T-cell killing response of gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BGC-823 gastric cancer cells.
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Concentration:1 μM, 2 μM
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Incubation Time:24 h, 48 h
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Result:Can effectively reduce the stemness and migration ability of gastric cancer cells.
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Cell Line:BGC-823 gastric cancer cells.
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Concentration:1 μM, 2 μM
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Incubation Time:5 days
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Result:The mRNA level of PD-L1 was reduced.
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Cell Line:BGC-823 gastric cancer cells.
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Concentration:1 μM, 2 μM
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Incubation Time:5 days
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Result:Can induce the accumulation of LSD1 substrate H3K4me1 and H3K4me2.
Inhibited the expression of CD44, OCT4, SOX2, and Nanog.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male 615 mice (15-20 g; 4-5 weeks) were subcutaneously injected MFC cells into the right axilla[1].
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Dosage:15 mg/kg, 25 mg/kg, 50 mg/kg
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Administration:Administered by gavage; daily ; for 14 consecutive days
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Result:The mice showed little change in body weight and no significant liver or kidney damage.
Inhibited the tumor growth of MFC cells in vivo in a dose-dependent manner.
Chemical Information
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CAS No. 2904571-94-2
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Appearance Solid
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분자량 355.48
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화학식 C24H25N3
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Color Yellow to orange
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SMILES
CC1=CC=C2C(C(NC3=CC=C(N(C)C)C=C3)=C4C(C(C)=C(C)C=C4)=N2)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Discovery of natural apigenin analogues as lysine-specific demethylase 1 inhibitors against tumoral testicular germ cells. [Abstract]2026 Mar 2;16(1):8917. PMID: 41772063
용액&용해도
DMSO : 100 mg/mL (281.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8131 mL | 14.0655 mL | 28.1310 mL | 70.3274 mL |
| 5 mM | 0.5626 mL | 2.8131 mL | 5.6262 mL | 14.0655 mL | |
| 10 mM | 0.2813 mL | 1.4065 mL | 2.8131 mL | 7.0327 mL | |
| 15 mM | 0.1875 mL | 0.9377 mL | 1.8754 mL | 4.6885 mL | |
| 20 mM | 0.1407 mL | 0.7033 mL | 1.4065 mL | 3.5164 mL | |
| 25 mM | 0.1125 mL | 0.5626 mL | 1.1252 mL | 2.8131 mL | |
| 30 mM | 0.0938 mL | 0.4688 mL | 0.9377 mL | 2.3442 mL | |
| 40 mM | 0.0703 mL | 0.3516 mL | 0.7033 mL | 1.7582 mL | |
| 50 mM | 0.0563 mL | 0.2813 mL | 0.5626 mL | 1.4065 mL | |
| 60 mM | 0.0469 mL | 0.2344 mL | 0.4688 mL | 1.1721 mL | |
| 80 mM | 0.0352 mL | 0.1758 mL | 0.3516 mL | 0.8791 mL | |
| 100 mM | 0.0281 mL | 0.1407 mL | 0.2813 mL | 0.7033 mL |
LSD1-IN-27 Related Classifications
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