2. Academic Validation
  3. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

  • Cancer Biol Ther. 2006 Mar;5(3):300-4. doi: 10.4161/cbt.5.3.2391.
J Matthew McDonald 1,  Sarah Dunlap,  David Cogdell,  Valerie Dunmire,  Qingyi Wei,  Anna Starzinski-Powitz,  Raymond Sawaya,  Janet Bruner,  Gregory N Fuller,  Kenneth Aldape,  Wei Zhang
Affiliations

Affiliation

  • 1 Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
PMID: 16410724 DOI: 10.4161/cbt.5.3.2391
Abstract

Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

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