N-Desmethyldauricine 

N-Desmethyldauricine is a NF-κB p65 inhibitor and apoptosis inducer. N-Desmethyldauricine reduces the protein expression level of p65, induces apoptosis, arrests the cell cycle at the G0/G1 phase, attenuates intercellular adhesion, and inhibits the growth of 3D spheroids of triple-negative breast cancer. N-Desmethyldauricine can be used in studies related to triple-negative breast cancer^[1].

N-Desmethyldauricine (72 h) potently inhibits the proliferation of human triple-negative breast cancer cell lines SUM159, HCC1937, MDA-MB-231, and MDA-MB-468, with IC₅₀ values ranging from 5.73 μM to 13.16 μM after 72 h of treatment^[1].
N-Desmethyldauricine (10-30 μM; 24 h) induces apoptosis in human triple-negative breast cancer SUM159 cells, increasing apoptotic cell percentage to 22.77% at 30 μM after 24 h, and upregulates the proapoptotic protein cleaved-poly-ADP-ribose polymerase 1 in a concentration-dependent manner^[1].
N-Desmethyldauricine (10-30 μM; 24 h) arrests the cell cycle of human triple-negative breast cancer SUM159 cells in the G0/G1 phase, with 79.8% of cells in G0/G1 at 30 μM after 24 h, and downregulates the G0/G1 phase-related proteins cyclin-dependent kinase 2 and cyclin D1 in a concentration-dependent manner^[1].
N-Desmethyldauricine (10-30 μM; 24 h) suppresses the migration of human triple-negative breast cancer SUM159 cells in a concentration-dependent manner, and downregulates the migration-related protein matrix metallopeptidase 9 in a concentration-dependent manner^[1].
N-Desmethyldauricine (10, 20, 40, 60 μM) downregulates the expression of p65, an important subunit of the NF-κB pathway, in human triple-negative breast cancer cells in vitro in a concentration-dependent manner^[1].
N-Desmethyldauricine (25-100 μM; 10 days) effectively suppresses the growth of human triple-negative breast cancer SUM159 3D tumor spheroids, with 83% growth inhibition at 100 μM after 10 days of treatment, and reduces cell-cell adhesion in spheroids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

610.74

C₃₇H₄₂N₂O₆

146763-55-5

COC(C=C(CCN1C)C([C@H]1CC2=CC=C(C=C2)OC3=CC(C[C@@H]4C5=CC(OC)=C(OC)C=C5CCN4)=CC=C3O)=C6)=C6OC

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu W, et al. N-desmethyldauricine from Menispermum dauricum DC suppresses triple-negative breast cancer growth in 2D and 3D models by downregulating the NF-κB signaling pathway. Chem Biol Interact. 2024;398:111113.  [Content Brief]