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Cat. No.: HY-179410

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Galectin-3-IN-7

Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a K_d of 5.7 nM and shows 390-fold selectivity over Gal-1. Galectin-3-IN-7 can downregulate profibrotic signaling such as ACTA2, COL1A2, and FN1 in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 can be used for the research of fibrosis.

For research use only. We do not sell to patients.

Formula: C₃₁H₃₄FN₅O₁₁S
Molecular Weight:703.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Galectin-3-IN-7 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Galectin-3

5.7 nM (Kd)

All Galectin Isoforms :

In Vitro

Galectin-3-IN-7 (Compound 11) exhibits moderate plasma protein binding rates of 45%, 43%, and 90% in human, mouse, and rat plasma respectively^[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) shows a CC₅₀ of >300 μM against HEK293, HepG2, THP-1, Jurkat E6.1 and LX2 cells^[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) does not significantly inhibit LPS (HY-D1056)-induced TNFα secretion in THP-1 macrophage-like cells^[1].
Galectin-3-IN-7 (3.7-300 μM, 48 h) dose-dependently downregulates the mRNA expression of ACTA2, COL1A2, and FN1 in TGFβ1-stimulated LX2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

LX2 cells
Concentration:

3.7, 11.1, 33.3, 100 and 300 μM
Incubation Time:

48 h
Result:

Reduced the mRNA expression of ACTA2, COL1A2, and FN1.

Chemical Information

Molecular Weight 703.69
Formula C₃₁H₃₄FN₅O₁₁S
SMILES

O=C(C1=CC2=C(C(N([C@H]3[C@H](O)[C@@H](O)[C@H](S[C@H]4[C@H](O)[C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@@H](O)[C@@H](CO)O4)[C@@H](CO)O3)C(C)=O)=C1)C=CN2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zýka J, et al. N-Aryl-N-Lactosylamides as Potent and Highly Selective Inhibitors of Galectin-3 with Antifibrotic Activity. J Med Chem. 2025;68(22):24624-24648. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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