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UK-5099

(Synonyms: PF-1005023)
56 Cited Publications
Customer Review

Based on 56 publication(s) in Google Scholar

UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 56396-35-1
  • Formula: C18H12N2O2
  • Molecular Weight:288.30
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • UK-5099 Chemical Structure
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • UK-5099 Chemical Structure
    UK-5099 Chemical Structure
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
  • Experimental Validation Results for UK-5099
CAS No.: 56396-35-1
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  • UK-5099 Chemical Structure
    UK-5099 Chemical Structure
    1/16
  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Naive Tigit−/− or Tigit+/+ CD4+ T cells were cultured under Th1- or Th17- polarizing condition for 5 d. UK5099 (20 μM), MSDC-0602 (10 μM), Etomoxir (ETO, 1 μM), or bis-2-(5-phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide (BPTES, 3 μM) was included for the last 48 h of culture. IFNγ, T-bet, IL-17A, and RORγt expression in CD4+ T cells were measured by flow cytometry.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Naive Tigit−/− or Tigit+/+ CD4+ T cells were cultured under Th1- or Th17- polarizing condition for 5 d. UK5099 (20 μM), MSDC-0602 (10 μM), Etomoxir (ETO,1 μM), or bis-2-(5-phenylacetamido-1, 2,4-thiadiazol-2-yl) ethyl sulfide (BPTES, 3 μM) was included for the last 48 h of culture. IFNγ, T-bet, IL-17A, and RORγt expression in CD4+ T cells were measured by flow cytometry.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     CD4+ T cells from HC or PM patients were stimulated with αCD3/CD28 in the presence of UK5099 (20 μM), recombinant human CD155-Fc (10 μg/ml), or control IgG1 for 3 d.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 15;16(1):4502. [Abstract]

    Customer Validation
     Immunoblot analysis of acetylated H3K9 and H3K27 in mouse CD4+ T cells and representative bands.Cells were stimulated with αCD3/CD28 for 3 days in the presence of UK5099 (20 μM), ETO, or BPTES.

  • 1/16

    UK-5099 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 3;15(1):6587. [Abstract]

    Customer Validation
     NIC cells were treated with 10μM UK5099, or DMSO as a control. Proliferation was assessed by Incucyte® to measure cell confluency in real time.

  • UK-5099