3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

  • Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. doi: 10.1016/j.bmcl.2008.11.060.
Robert T Hendricks  1 ,  Stacey R Spencer ,  James F Blake ,  Jay B Fell ,  John P Fischer ,  Peter J Stengel ,  Vincent J P Leveque ,  Sophie Lepogam ,  Sonal Rajyaguru ,  Isabel Najera ,  John A Josey ,  Steven Swallow
Affiliations
  • 1. Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA. [email protected]
PMID: 19070486 DOI: 10.1016/j.bmcl.2008.11.060
Abstract

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.

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