Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6

  • J Nat Prod. 2011 Aug 26;74(8):1751-6. doi: 10.1021/np200258h.
Peng Fu  1 ,  Shuxia Wang ,  Kui Hong ,  Xia Li ,  Peipei Liu ,  Yi Wang ,  Weiming Zhu
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 21770434 DOI: 10.1021/np200258h
Abstract

Five new bipyridine Alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC₅₀ values of 0.26 to 15.7 μM. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 μM.