Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core

  • J Nat Prod. 2017 Nov 22;80(11):3010-3013. doi: 10.1021/acs.jnatprod.7b00620.
Jiao-Jiao Li  1 ,  Guo-Dong Chen  1 ,  Hong-Xia Fan  1 ,  Dan Hu  1 ,  Zheng-Qun Zhou  1 ,  Kang-Hua Lan  1 ,  Hui-Ping Zhang  2 ,  Hideaki Maeda  2 ,  Xin-Sheng Yao  1 ,  Hao Gao  1  3
Affiliations
  • 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632, People's Republic of China.
  • 2. RIKEN Center for Life Science Technologies , Yokohama, Kanagawa 2300045, Japan.
  • 3. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210023, People's Republic of China.
PMID: 29099182 DOI: 10.1021/acs.jnatprod.7b00620
Abstract

Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MSn experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. A putative biosynthetic pathway of houttuynoid M (1) is proposed. The anti-herpes simplex virus (anti-HSV) activities of 1 and 2 (IC50 values of 17.72 and 12.42 μM, respectively) were evaluated using a plaque formation assay with acyclovir as the positive control.