Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401

  • J Nat Prod. 2018 Jun 22;81(6):1405-1410. doi: 10.1021/acs.jnatprod.8b00015.
Wei Fang  1  2 ,  Jianjiao Wang  2 ,  Junfeng Wang  2 ,  Liqiao Shi  1 ,  Kunlong Li  2 ,  Xiuping Lin  2 ,  Yong Min  1 ,  Bin Yang  2 ,  Lan Tang  3 ,  Yonghong Liu  2 ,  Xuefeng Zhou  2
Affiliations
  • 1. Hubei Biopesticide Engineering Research Center , Hubei Academy of Agricultural Science , Wuhan 430064 , China.
  • 2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology , Chinese Academy of Sciences , Guangzhou 510301 , China.
  • 3. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.
PMID: 29786436 DOI: 10.1021/acs.jnatprod.8b00015
Abstract

Three new eremophilane Sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and Antibacterial activities against five Cancer cell lines (IC50 1.4 to 4.3 μM) and three Bacterial species (MIC 1.5 to 13 μg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 μM, respectively. Further studies indicated that 3 induced Apoptosis in ACHN cells in a dose- and time-dependent manner.