Piperidine alkaloids and xanthone from the roots of Caulophyllum robustum Maxim

  • Fitoterapia. 2019 Jan;132:22-25. doi: 10.1016/j.fitote.2018.07.014.
Hui-Xiang Yang  1 ,  Wei Li  1 ,  Qian Li  1 ,  Hong-Lian Ai  1 ,  Zheng-Hui Li  1 ,  Rong Huang  1 ,  Tao Feng  2 ,  Ji-Kai Liu  3
Affiliations
  • 1. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
  • 2. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: [email protected].
  • 3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: [email protected].
PMID: 30056184 DOI: 10.1016/j.fitote.2018.07.014
Abstract

Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined by extensive spectroscopic techniques. Compounds 3 and 7 exhibited weak cytotoxicities against human palace Cancer hela cell line with inhibitory rates of 32.2% and 39.7%, respectively, at the concentration of 40 μM.

Keywords
Caulophyllum robustom; Cytotoxicity; Piperidines; Xanthone.
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