Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

  • Bioorg Med Chem Lett. 2020 Feb 15;30(4):126886. doi: 10.1016/j.bmcl.2019.126886.
Kouichi Sugaya  1 ,  Mutsumi Ino  1 ,  Naoki Matsuo  1 ,  Jun-Ichi Onose  2 ,  Naoki Abe  3
Affiliations
  • 1. Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  • 2. Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: [email protected].
  • 3. Department of Nutritional Science and Food Safety, Faculty of Applied Bio-Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Electronic address: [email protected].
PMID: 31879206 DOI: 10.1016/j.bmcl.2019.126886
Abstract

Variegatic acid, isolated from Tylopilus ballouii dry fruiting bodies, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL-2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively. On the Other hand, it inhibits PKCβ1 activity with an IC50 value of 36.2 μM.

Keywords
Allergy; Chemokine; Inflammatory response; Variegatic acid.
Products