Photochemistry of Cannabidiol (CBD) Revised. A Combined Preparative and Spectrometric Investigation

  • J Nat Prod. 2021 Nov 26;84(11):2858-2865. doi: 10.1021/acs.jnatprod.1c00567.
Paolo Seccamani  1 ,  Chiara Franco  1 ,  Stefano Protti  1 ,  Alessio Porta  1 ,  Antonella Profumo  1 ,  Diego Caprioglio  2 ,  Stefano Salamone  2 ,  Barbara Mannucci  3 ,  Daniele Merli  1  4
Affiliations
  • 1. Department of Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy.
  • 2. Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
  • 3. Centro Grandi Strumenti, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
  • 4. INFN Sezione di Milano-Bicocca, Piazza della Scienza 3, 20126 Milano, Italy.
PMID: 34668704 DOI: 10.1021/acs.jnatprod.1c00567
Abstract

Cannabis is a plant with an astonishing ability to biosynthesize cannabinoids, and more than 100 molecules belonging to this class have been isolated. Among them in recent years cannabidiol (CBD) has received the interest of pharmacology as the major nonpsychotropic cannabinoid with many potential clinical applications. Although the reactivity of CBD has been widely investigated, only little attention has been given to the possible photodegradation of this cannabinoid, and the data available in the literature are outdated and, in some cases, conflicting. The aim of the present work is providing a characterization of the photochemical behavior of CBD in organic Solvents, through a detailed GC-MS analyses, isolation, and NMR characterization of the photoproducts obtained.

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