Fusidane-Type Antibiotics from the Marine-Derived Fungus Simplicillium sp. SCSIO 41513

  • J Nat Prod. 2021 Nov 26;84(11):2945-2952. doi: 10.1021/acs.jnatprod.1c00776.
Xia Cheng  1  2 ,  Xiao Liang  1 ,  Fei-Hua Yao  1  2 ,  Xiao-Bo Liu  1  2 ,  Shu-Hua Qi  1  3
Affiliations
  • 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, Guangdong, China.
  • 2. University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 3. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.
PMID: 34755511 DOI: 10.1021/acs.jnatprod.1c00776
Abstract

Simplifusidic acids A-K (1-11), 11 new fusidane-type nortriterpenoids, were isolated from the marine-derived fungus Simplicillium sp. SCSIO 41513. Compound 1 possessed an unprecedented fusidane triterpene skeleton with a 6/6/7/5/5 polycyclic system. Their structures were elucidated by spectroscopic methods, and their absolute configurations were further determined by quantum chemical calculations of ECD spectra, comparison of experimental ECD spectra, and single-crystal X-ray diffraction analysis. Compound 9 showed strong Antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL. Their structure-bioactivity relationship was also discussed.

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