Efficient local delivery of FK506 using blocking patches in psoriasis

  • J Colloid Interface Sci. 2023 Jan 15;630(Pt A):676-687. doi: 10.1016/j.jcis.2022.09.146.
Zihan Zhao  1 ,  Huaiji Wang  2 ,  Lingling Yao  3 ,  Xilin Zhang  1 ,  Qian Yu  4 ,  Jun Gu  5 ,  Yuling Shi  6
Affiliations
  • 1. Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, 200443 Shanghai, China; Institute of Psoriasis, Tongji University School of Medicine, 200443 Shanghai, China.
  • 2. Department of Nephrology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, 200434 Shanghai, China.
  • 3. Institute of Psoriasis, Tongji University School of Medicine, 200443 Shanghai, China; Department of Dermatology, Shanghai Clinical College of Anhui Medical University, 230000 Hefei, China; Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 200072 Shanghai, China.
  • 4. Institute of Psoriasis, Tongji University School of Medicine, 200443 Shanghai, China; Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 200072 Shanghai, China. Electronic address: [email protected].
  • 5. Institute of Psoriasis, Tongji University School of Medicine, 200443 Shanghai, China; Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 200072 Shanghai, China. Electronic address: [email protected].
  • 6. Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, 200443 Shanghai, China; Institute of Psoriasis, Tongji University School of Medicine, 200443 Shanghai, China. Electronic address: [email protected].
PMID: 36274404 DOI: 10.1016/j.jcis.2022.09.146
Abstract

FK506 is a local drug that is commonly used in the treatment of psoriasis. Its clinical application, however, is limited by its transdermal drug delivery rate, the time-consuming, and the greasy therapy. In this study, which was inspired by local block injection used in the clinical treatment for keloid, a hyaluronic acid (HA) based system to transport FK506 into the skin to treat psoriasis, named blocking patch (BP) was developed. BP has a complete appearance, sufficient puncture strength, and is virtually non-irritating in vivo. By confocal fluorescence microscopy, BP loaded with FK506 (FK506-BP) showed satisfactory transdermal release ability in vivo. Further animal studies revealed that FK506-BP showed a good anti-inflammatory ability in the imiquimod (IMQ)-induced mouse psoriasis-like dermatitis and inhibited the activation of associated immune cells. This study indicates that BP as a novel delivery system, realizes an efficient local delivery of FK506 in psoriasis and holds great potential in transdermal delivery.

Keywords
Anti-inflammation; Blocking patch; FK506; Microneedle; Psoriasis; Skin; Transdermal drug delivery.
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