Widely targeted quantitative lipidomics reveal lipid remodeling in adipose tissue after long term of the combined exposure to bisphenol A and fructose

  • Hum Exp Toxicol. 2024 Jan-Dec:43:9603271241232609. doi: 10.1177/09603271241232609.
Yonghong Tang  1 ,  Guifang Ou  1 ,  Ouyan Rang  1 ,  Xu Liu  1  2 ,  Xiaocheng Liu  1 ,  Xinru Qin  1  2 ,  Guojuan Li  3 ,  Qing Yang  1 ,  Mu Wang  1
Affiliations
  • 1. Clinical Mass Spectrometry Laboratory of Clinical Research Institute and Department of Basic Medicine of Nuclear Industrial Hygiene School, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
  • 2. School of Public Health, University of South China, Hengyang, China.
  • 3. Endocrinology Department, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
PMID: 38320548 DOI: 10.1177/09603271241232609
Abstract

Adipose tissue is the main organ that stores lipids and it plays important roles in metabolic balance in the body. We recently reported in Human and Experimental Toxicology that the combined exposure to BPA and fructose may interfere with energy metabolism of adipose tissue. However, it is still unclear whether the combined exposure to BPA and fructose has the possibility to induce lipid remodeling in adipose tissue. In the present study, we performed a widely targeted quantitative lipidomic analysis of the adipose tissue of rats after 6 months of BPA and fructose combined exposure. We totally determined 734 lipid molecules in the adipose tissue of rats. Principal component analysis (PCA) showed the group of the combined exposure to higher-dose (25 μg/kg every Other day) BPA and fructose can be distinguished from the groups of control, higher-dose BPA exposure and fructose exposure clearly. Partial least squares-discriminant analysis (PLS-DA) and univariate statistical analysis displayed lipids of PC(18:0_ 20:3), TG(8:0_14:0_16:0), TG(12:0_14:0_16:1), TG(10:0_16:0_16:1), TG(12:0_ 14:0_18:1), TG(14:0_ 16:0_16:1), TG(14:0_14:1_16:1), TG(8:0_ 16:1_16:2), TG(14:1_16:1_ 16:1), TG(16:1_18:1_18:1), TG(16:0_16:1_20:4) and TG(15:0_18:1_ 24:1) may contributed the most to the discrimination. These findings indicated that combined exposure to BPA and fructose has the potential to cause lipid remodeling in adipose tissue.

Keywords
BPA; Widely targeted quantitative lipidomics; adipose tissue; fructose.
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