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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
rnase-h1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "rnase-h1" in MCE Product Catalog:
Referencia número: HY-112974
No. CAS: 1492984-65-2
Synonyms: GSK-2998728; ISIS-420915
Target:
Áreas de investigación:
Inotersen (GSK-2998728; ISIS-420915) is a 2'-O-methoxyethyl-modified antisense oligonucleotide and transthyretin (TTR) inhibitor with low genotoxicity. Inotersen triggers RNase H1-mediated degradation by binding to TTR mRNA, thereby effectively reducing the production of both mutant and wild-type transthyretin in the liver. Inotersen significantly reduces amyloid fiber deposition, yet specific toxicities such as inflammation or tumors are observed at high doses in some animal models. Inotersen is used in studies of hereditary transthyretin amyloidosis and the associated polyneuropathy and cardiomyopathy [1] .
Referencia número: HY-145725A
No. CAS: 1698048-23-5
Synonyms: ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx
Target:
Áreas de investigación:
Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits DMPK mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 [1].
Referencia número: HY-RS12024
Target:
Áreas de investigación:
RNASEH1 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASEH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-P702773
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Ribonuclease H type II; Ribonuclease h1; RNh1; rnase h1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
