1 Result for "

A57696

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "A57696" in MCE Product Catalog:

Cat. No.: HY-P2055
CAS No.: 125598-87-0
Target:  

Endogenous Metabolite

Research Areas:  

Endocrinology

A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM). A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay .
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