1 Result for "

ACT-077825

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ACT-077825" in MCE Product Catalog:

Cat. No.: HY-12172
CAS No.: 903579-36-2
Synonyms: ACT-077825
Target:  

Renin

Research Areas:  

Cardiovascular Disease

MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
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