1 Result for "

APC-d3

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "APC-d3" in MCE Product Catalog:

  • Targets Recommended:
Cat. No.: HY-P11035
Target:  

Ephrin Receptor

Research Areas:  

Neurological Disease Cancer

APY-d3 is a highly selective EphA4 receptor inhibitor, with an IC50 value of 17-56 nM for human EphA4, an IC50 value of 20 nM for mouse EphA4, and a Kd value of 138 nM for EphA4-LBD. APY-d3 binds to EphA4, blocks its interaction with ephrin ligands, inhibits tyrosine phosphorylation of EphA4, prevents growth cone collapse, and does not induce EphA4 phosphorylation in primary cortical neurons. APY-d3 adopts a β-hairpin conformation stabilized by an N-terminal to C-terminal disulfide bond. APY-d3 can be used in research related to amyotrophic lateral sclerosis, Alzheimer's disease, stroke, neurodegenerative diseases and cancer .
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