1 Result for "

ART-5803

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ART-5803" in MCE Product Catalog:

Cat. No.: HY-P991611
CAS No.: 3058434-76-4

Target:  

iGluR

Research Areas:  

Inflammation/Immunology

ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis .
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