1 Result for "

AT 1413

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "AT 1413" in MCE Product Catalog:

AT-1413
AT-1413
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Cat. No.: HY-P991425

Target:  

Transmembrane Glycoprotein

Research Areas:  

Cardiovascular Disease Cancer

AT-1413 is a monoclonal antibody targeting CD43s that recognizes a unique sialylated CD43 epitope spanning amino acid residues 133-165. AT1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in AML cells, with EC50 values of 1.1 nM and 12.4 nM, respectively. AT-1413 binds to a variety of cancer cells, shows weak binding to non-malignant myeloid cells and endothelial cells, and does not bind to healthy lymphoid cells or normal non-hematopoietic cells. AT1413 clears CD43s-expressing leukemic blasts in vivo without affecting non-malignant myeloid cells. AT-1413 can be used in research related to acute myeloid leukemia, myelodysplastic syndrome, melanoma, and breast cancer .
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