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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
ATP6
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "ATP6" in MCE Product Catalog:
5
5 Cited Publications
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EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .
Cat. No.: HY-P2657
CAS No.: 138067-14-8
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Synonyms: Nec-7
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Necrostatin-7 (Nec-7) is a Necroptosis inhibitor with an EC50 of 10.6 μM. Necrostatin-7 inhibits signal transduction from RANK to NFATc1 without affecting the activation of MAPK or NF-κB. Necrostatin-7 suppresses the expression levels of Acp5, Atp6v0d2, Ctsk and Dcstamp. Necrostatin-7 reduces myocardial infarction size, ameliorates adverse left ventricular remodeling, decreases myocardial wall stress, reduces the amount and length of scar tissue, and improves left ventricular function. Necrostatin-7 exerts cardioprotective effects in a rat model of permanent coronary artery occlusion. Necrostatin-7 can be used in research related to osteolytic bone diseases and myocardial infarction .
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6-Me-ATP (N6-Methyl-ATP) is an N 6-modified ATP derivative. 6-Me-ATP exhibits excellent binding affinity for GSK3 and acts as a phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptides. 6-Me-ATP is applicable to research related to Alzheimer's disease .
Cat. No.: HY-RS01225
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ATP6V1B2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08751
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MT-ATP6 Human Pre-designed siRNA Set A contains three designed siRNAs for MT-ATP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS29446
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ATP6V1A Monkey Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1A gene (Monkey), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01217
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ATP6V0A2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V0A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
PHY34 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer .
Cat. No.: HY-P704166
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MT-ATP6; ATP6; ATPASE6; MTATP6; ATP synthase subunit a; F-ATPase protein 6
Cat. No.: HY-RS01214
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ATP6AP1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6AP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01215
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ATP6AP2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6AP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01223
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ATP6V1A Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18574
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Atp6v1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atp6v1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01230
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ATP6V1F Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01219
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ATP6V0B Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V0B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01220
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ATP6V0C Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V0C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01228
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ATP6V1D Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01234
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ATP6V1H Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1H gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
