2 Results for "

Aprutumab

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Aprutumab" in MCE Product Catalog:

Aprutumab
Aprutumab
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Cat. No.: HY-P99007
CAS No.: 1634620-63-5
Synonyms: BAY 1179470

Target:  

FGFR

Research Areas:  

Cancer

Aprutumab (BAY 1179470) is a fully human fibroblast growth factor receptor 2 (FGFR2)-specific monoclonal antibody . Aprutumab induces FGFR2 endocytosis and degradation in cancer cells expressing FGFR2. Aprutumab serves as the targeted monoclonal antibody component of the antibody-drug conjugate BAY 1187982 (HY-141600) and mediates the endocytosis of the antibody-drug conjugate into FGFR2-positive cells. Aprutumab can be used for the research of FGFR2-positive solid tumors, including studies on gastric cancer and triple-negative breast cancer .
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Aprutumab ixadotin
Aprutumab ixadotin
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Cat. No.: HY-141600
CAS No.: 1708947-48-1
Purity:  98.99%
Synonyms: BAY 1187982

Target:  

Antibody-Drug Conjugates (ADCs) FGFR Microtubule/Tubulin Apoptosis

Research Areas:  

Cancer

Aprutumab ixadotin (BAY 1187982) is the first antibody-drug conjugate (ADC) to target FGFR2 and the first to use Auristatin-based payload. Aprutumab ixadotin contains a fully human anti-FGFR2 monoclonal antibody (Aprutumab) (HY-P99007) conjugated by lysine side chains to a non-cleavable linker and via this an innovative Auristatin W derivative. Aprutumab ixadotin can be used for the study of advanced solid tumors, such as FGFR2-positive gastric cancer and triple-negative breast cancer .
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