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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Ataxin-3
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Ataxin-3" in MCE Product Catalog:
Synonyms: ASC-JM17; ALZ-003
Target:
Keap1-Nrf2 Androgen Receptor HSP Mitophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy
Research Areas:
Rosolutamide (ASC-JM17) is an orally active Nrf1/Nrf2 activator. Rosolutamide activates Hsf1 pathways, upregulates proteasome subunits and antioxidant enzymes, induces proteasome complex structural rearrangement, and enhances ubiquitin-proteasome system-mediated degradation. Rosolutamide reduces mutant androgen receptor and ataxin-3 aggregates, restores mitochondrial function, attenuates reactive oxygen species (ROS) levels, induces apoptosis and ferroptosis, and inhibits cancer cell growth. Rosolutamide can be used for the research of spinal and bulbar muscular atrophy, Huntington’s disease, and temozolomide-resistant glioblastoma [3] .
Cat. No.: HY-172672
Target:
Research Areas:
Orexin 2 Receptor Agonist 3 (Compound 57) is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy .
Cat. No.: HY-P82432A
Synonyms: ATX1; SCA1; D6S504E
Cat. No.: HY-RS19985
Target:
Research Areas:
Atxn3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atxn3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701460
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATXN3L; Ataxin-3-like protein; Machado-Joseph disease protein 1-like
Species:
Source:
Cat. No.: HY-P701461
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATXN3L; Ataxin-3-like protein; Machado-Joseph disease protein 1-like
Species:
Source:
- 1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
