ATXN3L Protein, Human (sf9, FLAG)
The ATXN3L protein is a deubiquitinating enzyme that exhibits multiple activities by cleaving “Lys-48”-linked and “Lys-63”-linked polyubiquitin chains in vitro. It functions as a specific deubiquitinase for the transcription factor KLF5 and contributes to the stability regulation of KLF5. ATXN3L Protein, Human (sf9, FLAG) is the recombinant human-derived ATXN3L protein, expressed by sf9 insect cells , with C-Flag labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The ATXN3L protein is a deubiquitinating enzyme that exhibits multiple activities by cleaving “Lys-48”-linked and “Lys-63”-linked polyubiquitin chains in vitro. It functions as a specific deubiquitinase for the transcription factor KLF5 and contributes to the stability regulation of KLF5. ATXN3L Protein, Human (sf9, FLAG) is the recombinant human-derived ATXN3L protein, expressed by sf9 insect cells , with C-Flag labeled tag.
Background
ATXN3L Protein, functioning as a deubiquitinating enzyme, demonstrates versatile activity by cleaving both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains in vitro. Moreover, it serves as a specific deubiquitinase for the transcription factor KLF5, thereby contributing to the regulation of KLF5 stability. The dual capacity of ATXN3L to modulate diverse ubiquitin linkages and interact with specific transcription factors underscores its role in the dynamic regulation of cellular processes and protein stability, revealing its significance in the intricate landscape of cellular homeostasis.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag C-Flag
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Accession
Q9H3M9 (D2-K355)
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Gene ID92552
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Molecular Construction
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N-term
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ATXN3L (D2-K355)
Accession # Q9H3M9 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
ATXN3L; Ataxin-3-Like Protein; Ataxin 3 Like; Putative Ataxin-3-Like Protein; MJDL; Ataxin 3-Like; Machado-Joseph Disease Protein 1-Like; ATX3L
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AA Sequence
DFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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