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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Ataxin 3 Antibody (YA1294)

Ataxin 3 Antibody (YA1294)

Cat. No.: HY-P81549
User Guide for Antibodies Technical Support

Ataxin 3 Antibody (YA1294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ataxin 3.

For research use only. We do not sell to patients.

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50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Ataxin 3 Antibody (YA1294) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ataxin 3.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 41 kDa;
Observed band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Peptide
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P-1
 
50-1:100
Sensitivity Endogenous Purity Protein A
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, Glycerol and BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460)
Subcellular Localization：Nucleus matrix; Nucleus; Lysosome membrane; Peripheral membrane protein
Expression：
Tissue_specificity:Ubiquitous
Isoforms & Post-Translational Modification：P54252 has 5 isomers: P54252-2: 41250 Da (predicted); P54252-1: 41781 Da (predicted); P54252-3: 35006 Da (predicted); P54252-4: 39638 Da (predicted); P54252-5: 20633 Da (predicted).
Monoubiquitinated N-terminally by UBE2W, possibly leading to activate the deubiquitinating enzyme activity (PubMed:23696636)
Subunit：Interacts with DNA repair proteins RAD23A and RAD23B (PubMed:16020535, PubMed:30455355). Interacts with BECN1 (via its poly-Gln domain) (PubMed:28445460). Interacts with PRKN, UBR2, VCP and tubulin. Short isoform 1 interacts with CASP7 (PubMed:30455355)
Database

Entrez Gene: 4287 Human ; 110616 Mouse ; 60331 Rat

SwissProt: P54252 Human ; Q9CVD2 Mouse ; O35815 Rat

OMIM: 109150 Human

Research Field

Neuroscience
Synonyms
ATX3, MJD, MJD1, SCA3, ATXN3
Documentation
User Guide for Antibodies (1077 KB)

Ataxin 3 Antibody (YA1294) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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