ATXN3L Protein, Human (sf9, His, FLAG)

The ATXN3L protein is a deubiquitinating enzyme that exhibits multiple activities by cleaving “Lys-48”-linked and “Lys-63”-linked polyubiquitin chains in vitro. It functions as a specific deubiquitinase for the transcription factor KLF5 and contributes to the stability regulation of KLF5. ATXN3L Protein, Human (sf9, His, FLAG) is the recombinant human-derived ATXN3L protein, expressed by sf9 insect cells , with C-Flag, N-8*His labeled tag.

ATXN3L Protein, functioning as a deubiquitinating enzyme, demonstrates versatile activity by cleaving both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains in vitro. Moreover, it serves as a specific deubiquitinase for the transcription factor KLF5, thereby contributing to the regulation of KLF5 stability. The dual capacity of ATXN3L to modulate diverse ubiquitin linkages and interact with specific transcription factors underscores its role in the dynamic regulation of cellular processes and protein stability, revealing its significance in the intricate landscape of cellular homeostasis.

Human

Sf9 insect cells

C-Flag;N-8*His

Q9H3M9 (D2-K355)

92552

Partial

DFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.