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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
BY13
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "BY13" in MCE Product Catalog:
Cat. No.: HY-176225
Target:
Research Areas:
BY13 is a SRC-3 PROTAC degrader with a DC50 of 0.031 μM. BY13 selectively blocks the ER signaling pathway over that of androgen receptor (AR)) through down-regulating ERα level. BY13 potently overcomes endocrine resistance in breast cancer by inducing cell cycle arrest in G1 phase and apoptosis, with superior effect over Fulvestrant (HY-13636). BY13 significantly inhibits the growth of drug-resistant breast tumors without obvious toxicity in LCC2 xenograft mice model .
Cat. No.: HY-176226
Target:
Research Areas:
Piperidine-azetidine-Br is a PROTAC linker that can be used in the synthesis of PROTACs, such as BY13 (HY-176225) .
Cat. No.: HY-176227
Research Areas:
Thalidomide-piperidine-azetidine-Br is an E3 ligase ligand-linker conjugate that incorporates the
Thalidomide (HY-14658) based CRBN ligand (HY-41547) and linker (HY-176226). Thalidomide-piperidine-azetidine-Br can be used for synthesis of BY13 (HY-176225) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
