5 Results for "

Bisdemethoxycurcumin

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Bisdemethoxycurcumin" in MCE Product Catalog:

Bisdemethoxycurcumin
Bisdemethoxycurcumin
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Cat. No.: HY-N2942
CAS No.: 52328-96-8
Category:  

Ketones, Aldehydes, Acids Alpinia officinarum Hance Plants Zingiberaceae

Target:  

PI3K Akt p38 MAPK PDK-1 mTOR Autophagy AMPK Keap1-Nrf2 Interleukin Related TNF Receptor NOD-like Receptor (NLR) Pyroptosis Bacterial

Bisdemethoxycurcumin is an orally effective curcuminoid. Bisdemethoxycurcumin downregulates pro-inflammatory cytokines in macrophages by inhibiting the phosphorylation of PI3K/Akt and p38 MAPK. Bisdemethoxycurcumin relieves autophagy inhibition and promotes lipophagy to clear vascular smooth muscle foam cells by inhibiting the PDK1/Akt/mTOR pathway. Bisdemethoxycurcumin activates the cAMP/Epac/AMPKα axis and the NRF2/HO-1 antioxidant axis, thereby indirectly inhibiting the phosphorylation of NF-κB p65 and pro-inflammatory outputs such as IL-1β/IL-6/TNF-α, so as to alleviate pulmonary oxidative stress, inflammatory infiltration and pulmonary edema. Bisdemethoxycurcumin blocks NLRP3-mediated pyroptosis and protects cartilage extracellular matrix degradation by activating NRF2/HO-1. Bisdemethoxycurcumin also exerts a synergistic effect with potassium iodide against Candida .
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(E,E)-Bisdemethoxycurcumin
(E,E)-Bisdemethoxycurcumin
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4 Cited Publications
Cat. No.: HY-N0007
CAS No.: 33171-05-0
Synonyms: (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin
Category:  

Zingiber officinale Roscoe Phenols Polyphenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

Apoptosis Autophagy

(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
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Diphenyliodonium iodide
Diphenyliodonium iodide
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1 Cited Publications
Cat. No.: HY-W250307
CAS No.: 2217-79-0
Diphenyliodonium iodide is an inhibitor of reactive oxygen species (ROS). Diphenyliodonium iodide can inhibit the accumulation of bisdemethoxycurcumin in fresh-cut yam by inhibiting the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, thereby preventing the yellowing of fresh-cut yam. Diphenyliodonium iodide can be used in medicine and fruit preservation .
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(E,E)-Bisdemethoxycurcumin (Standard)
(E,E)-Bisdemethoxycurcumin (Standard)
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Cat. No.: HY-N0007R
CAS No.: 33171-05-0
Synonyms: (E,E)-Curcumin III (Standard); (E,E)-Didemethoxycurcumin (Standard)
Category:  

Zingiber officinale Roscoe Phenols Polyphenols Plants Zingiberaceae

Target:  

Reference Standards Apoptosis Autophagy

(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .
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Bisdemethoxycurcumin-d8
Bisdemethoxycurcumin-d8
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Cat. No.: HY-N0007S
CAS No.: 2470233-08-8
Synonyms: Curcumin III-d8; Didemethoxycurcumin-d8
Bisdemethoxycurcumin-d8 (Curcumin III-d8) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .
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