2 Results for "

Braftide

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Braftide" in MCE Product Catalog:

TAT-Braftide
TAT-Braftide
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Cat. No.: HY-P10438
Target:  

Raf

Research Areas:  

Cancer

TAT-Braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by TAT-Braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .
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Braftide
Braftide
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Cat. No.: HY-P10436
CAS No.: 2411851-64-2
Target:  

Raf

Research Areas:  

Cancer

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research .
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