3 Results for "

CD47 ligand

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "CD47 ligand" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99700
CAS No.: 2283356-07-8
Synonyms: IBI-188

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Letaplimab (IBI-188) is a human IgG4 anti-CD47 monoclonal antibody. CD47 is overexpressed on cancer cells, it is a ligand for SIRPα. Letaplimab enhances tumor cell phagocytosis .
loading...
    loading...
Cat. No.: HY-P10420
CAS No.: 2415545-08-1
Research Areas:  

Cancer

RS17 is an anti-tumor peptide designed to bind specifically to the CD47 molecule and block the interaction between CD47 and its ligand, SIRPα, on the surface membrane of macrophages. The main regulatory mechanism of RS17 is to prevent CD47 from transmitting selective phagocytosis signals to SIRPα by binding to CD47, so that macrophages do not recognize tumor cells as their own tissue, but phagocytose them as foreign substances, thereby inhibiting immune escape of tumor cells. RS17 can be used to study the mechanism of anti-tumor response and immune escape .
loading...
    loading...
loading...
    loading...