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CNGA2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Drug Derivative (1) Fluorescent Dye (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cardiovascular Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS02880

CNGA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CNGA2 Human Pre-designed siRNA Set A contains three designed siRNAs for CNGA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CNGA2 Human Pre-designed siRNA Set A CNGA2 Human Pre-designed siRNA Set A

HY-RS28971

Cnga2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cnga2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cnga2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cnga2 Rat Pre-designed siRNA Set A Cnga2 Rat Pre-designed siRNA Set A

HY-RS22448

Cnga2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cnga2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cnga2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cnga2 Mouse Pre-designed siRNA Set A Cnga2 Mouse Pre-designed siRNA Set A

HY-116540A

L 858051 dihydrochloride 7DMB-Forskolin	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes ^[2] .

HY-175080

8-DY547-cGMP	Drug Derivative Fluorescent Dye	Others
8-DY547-cGMP is a fluorescent cGMP analogue composed of a dye DY547 to position 8 of cGMP. 8-DY547-cGMP is a Cyclic nucleotide-gated A2 (CNGA2) ligand. 8-DY547-cGMP can activated CNGA2 channel. 8-DY547-cGMP can be used for simultaneously detection CNG channel activation and ligand binding .

HY-116540

L 858051 7DMB-Forskolin free base	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes ^[2] .

CNGA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CNGA2 Human Pre-designed siRNA Set A contains three designed siRNAs for CNGA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cnga2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cnga2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cnga2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cnga2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cnga2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cnga2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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