1 Result for "

CPT-Se4

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "CPT-Se4" in MCE Product Catalog:

Cat. No.: HY-145291
CAS No.: 2968315-03-7
Target:  

Topoisomerase Apoptosis

Research Areas:  

Cancer

CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 μM) .
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