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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
DDO 3602
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "DDO 3602" in MCE Product Catalog:
Cat. No.: HY-178496
Target:
Research Areas:
DDO3602 is a PARP1 HSPTAC (HSP90-mediated proteolysis-targeting chimera) degrader, with a DC50 of 490.3 nM against PARP1; its Kd values for PARP1 and HSP90 are 66.5 nM and 1.64 nM, respectively. DDO3602 induces the formation of an unnatural PARP1-HSP90 ternary complex, recruits E3 ubiquitin ligase, and promotes PARP1 degradation via the ubiquitin-proteasome pathway. DDO3602 induces G2/M cell cycle arrest, DNA damage, inhibits cell migration, and exhibits antiproliferative activity in breast cancer cells. DDO3602 can be used in breast cancer-related research .
Cat. No.: HY-179208
CAS No.: 2631575-47-6
Research Areas:
N-Descyclopropanecarbaldehyde Olaparib suberic acid is a ligand-linker conjugate that can be used for the synthesis of DDO3602 (HY-178496) .
Cat. No.: HY-179203
CAS No.: 2355276-57-0
Target:
Research Areas:
N-Demethylonalespib is a ligand for E3 ligase. N-Demethylonalespib can be used for synthesis of DDO3602 (HY-178496) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
