Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
DFG motif
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "DFG motif" in MCE Product Catalog:
Cat. No.: HY-187462
CAS No.: 3080682-21-6
Target:
Research Areas:
Kit-IN-1 is a kinome-selective and orally active KIT inhibitor with a human IC50 value of 2.8 nM. Kit-IN-1 binds to KIT in an allosteric mode, stabilizes the inactive DFG-out conformation of KIT, and blocks the stem cell factor (SCF)-mediated KIT phosphorylation signaling pathway. Kit-IN-1 inhibits SCF-induced ear swelling in rats and prevents increased vascular permeability. Kit-IN-1 can be used in studies related to mast cell-driven chronic inflammation .
Cat. No.: HY-183779
CAS No.: 3091622-68-0
Antiangiogenic agent 10 is a potent orally active antiangiogenic agent with antiproliferative activity against breast cancer cells. Antiangiogenic agent 10 induces apoptosis via caspase-3 activation. Antiangiogenic agent 10 can be used for the research of breast cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
