1 Result for "

Didrovaltrate

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Didrovaltrate" in MCE Product Catalog:

Didrovaltrate
Didrovaltrate
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Cat. No.: HY-N3741
CAS No.: 18296-45-2
Synonyms: Didrovaltratum
Category:  

Natural Products Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer

Target:  

Calcium Channel Reactive Oxygen Species (ROS) Autophagy

Didrovaltrate (Didrovaltratum) is an L-type calcium channel blocker, ROS scavenger, autophagy enhancer, and lipid accumulation inhibitor. Didrovaltrate blocks L-type calcium currents in a concentration-dependent manner, shifts the current-voltage curve upward, modulates steady-state inactivation kinetics, and inhibits the nuclear translocation of glucocorticoid receptors. Didrovaltrate reduces ROS levels, downregulates the expression of muscle atrophy-related genes, enhances autophagy via lipophagy, and decreases Oleic acid-induced lipid accumulation. Didrovaltrate exhibits cytotoxic activity against cancer cells. Didrovaltrate can be used in research related to skeletal muscle atrophy, non-alcoholic fatty liver disease, breast cancer, lung cancer, gastric cancer, and prostate cancer .
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