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Dithioether derivatives

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-179637
    RNAP-σ interaction-IN-4

    		Bacterial DNA/RNA Synthesis Infection
    RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the RNA polymerase-sigma factor interaction (RNAP-σ) with MIC values against S. pneumoniae and S. aureus of 1 μg/mL and 2 μg/mL, respectively. RNAP-σ interaction-IN-4 exhibits strong bactericidal properties by interfering with the interaction of β′CH−σ and disrupting the transcription of bacteria. RNAP-IN-2 shows significant efficacy in sepsis models. RNAP-σ interaction-IN-4 can be used to study Gram-positive bacterial infections caused by multi-drug resistant strains .
    RNAP-σ interaction-IN-4

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